Impact of the COVID-19 Pandemic on Children and Adolescents with New-Onset Type 1 Diabetes

Background. The COVID-19 pandemic has an impact on the incidence of type 1 diabetes and frequency diabetic ketoacidosis. However, exact relationships are unclear. It is also not known whether this a short-term phenomenon or effects have long-term relevance. Furthermore, it these changes during due to direct SARS-CoV-2 in patient’s environment pandemic. Methods. We conducted extensive literature search PubMed. For estimation relative risks new-onset diabetes, we applied Poisson regression model for comparison incidences included logarithm person-years. performed meta-analysis using risk as effect size. Results. Pooling estimates random-effects revealed that rate increased by 20% (relative 1.200 (95% CI 1.125, 1.281)), after infection 62% 1.622 1.347, 1.953)) compared with prepandemic period. Conclusion. There considerable evidence there increase children Many studies suggesting methodological weaknesses. As no presymptomatic cases isolated islet autoimmunity was found, could suggest accelerated transition from patients clinically overt diabetes. marked exacerbation preexisting prevalence ketoacidosis at diagnosis Both paediatric higher led massive rise number